七色视频

Education

• HSBc (University of Toronto)
• MSc (McMaster University)
• PhD (University of Waterloo)
• Postdoctoral Research Fellow (The Hospital for Sick Children (SickKids))

Research interests

Dr. Yeung鈥檚 overarching research goal is translating mathematical models to significantly advance our understanding of drug pharmacokinetics in understudied populations. Her focus is on reducing adverse drug reactions and improving patient health among populations often left out of the drug development process including preterm infants, neonates, and breastfeeding maternal-infant dyads. Dr. Yeung has three research aims: 1) Discover and overcome barriers to implementing model-informed precision dosing for commonly administered drugs in the Neonatal Intensive Care Unit using population pharmacokinetic (popPK) modeling; 2) Establish accuracy and precision of drug exposure predictions in preterm infants using an improved preterm physiologically based pharmacokinetic (PBPK) model; and 3) Identify drugs for infant breastfeeding risk prioritization and increase clinician certainty in advising breastfeeding mothers taking medications.

Selected awards and honours

• Alumni Achievement Award, School of Pharmacy, University of Waterloo 2024
• Banting Postdoctoral Fellowship, Canadian Institutes of Health Research
• Restracomp Fellowship, The Hospital for Sick Children (SickKids)

Selected publications

• 听Yeung CHT, Verstegen RHJ, Greenberg R, Lewis TR. Pharmacokinetic and pharmacodynamic principles: Unique considerations for optimal design of neonatal clinical trials. Front Pediatr. 2024;11:1345969.
• Yeung CHT, Autmizguine J, Dalvi P, Denoncourt A, Ito S, Katz P, Rahman M, Theoret Y, Edginton AN. Maternal ezetimibe concentrations measured in breast milk and its use in breastfeeding infant exposure predictions. Clinical Pharmacokinet. 2024;1-16.
• Yeung CHT, Bertrand KA, Best BM, Capparelli E, Chambers CD, Hajducek DM, Hamadeh A, Ito S, Momper JD, Edginton AN. Cannabidiol exposure through maternal marijuana use: Predictions in breastfed infants. Clin Pharmacokinet. 2023.
• Yeung CHT, Houle SKD, Anderson PO, Best BM, Dubinsky S, Edginton AN. Addressing maternal medication use during breastfeeding using clinical resources and a novel physiologically based pharmacokinetic model-derived metric: A qualitative study. Front Pediatr. 2023 Apr 3;11:1147566.
• Yeung CHT, Beers JL, Jackson KD, Edginton AN. Verifying in vitro-determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically-based pharmacokinetic modeling. CPT Pharmacometrics Syst Pharmacol. 2022;12(3):320-332.